Optimize Thiopurine Therapy in Autoimmune Hepatitis

Autoimmune hepatitis

Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and ...

cyclosporine therapy for autoimmune hepatitis in children

background: the current immunosuppressive treatment of patients with autoimmune hepatitis (aih) consists of prednisolone and azathioprine. high doses of prednisolone used for disease remission are not universally effective and have serious adverse effects. some authors have provided evidence of aih therapy in children and adults with cyclosporine (neoral) should corticosteroid therapy become in...

Allopurinol safely and effectively optimises thiopurine metabolites in autoimmune hepatitis patients

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.

Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy ...

Childhood Autoimmune Hepatitis in Bahrain: a Tertiary Center Experience

Background: Autoimmune hepatitis (AIH) in childhood has variable modes of presentation, and the disease should be suspected and excluded in all children presenting with symptoms and signs of prolonged or severe acute liver disease. In AIH, the liver biopsy histopathology shows inflammation in addition to presence of serum autoimmune antibodies and increased levels of immunoglobulin G (IgG). Ob...